Winter 2022 - M101B is the hardest in the series in my opinion. The lectures are quite dense and there's many details to grasp. Cannon's module is just electrophysiology in the context of motor disorders mostly (so Chandler's module on steroids) and wasn't that fun. Babiec's module is all about receptors and synaptic transmission and you go super in-depth into how synapses form and the proteins involved in the NT release, etc. Orkun Akin's module is neurodevelopment (from how we start as a bundle of cells to how axons know where to go) and it is super dense. There are weekly quizzes due before discussion section - usually 3 MC and 1 free response. Try not to miss points on these - they are entirely doable if you just watch lecture. The exams are open-note and formatted as 5-6 MC and/or 5-6 free response due in an hour. This wasn't really a problem until the third module where each free response had 3 subparts that could stand alone as their own question, meaning effectively there were 6 MCs and 18 free response questions. Needless to say, everyone was mad because no one really finished. They say they don't curve the class, but I think I would've gotten a B+ (got 80/89/89 on the three exams) if they didn't, so I'm sure they're somewhat lenient. Overall, the content is quite interesting, you get a in-depth sneak peek and some of the coolest parts of neuroscience that previously you only got a surface-level understanding of, but the exams will dock you for the smallest things so be specific in your answers and make sure you know your stuff (even though it is open note) and be able to convey it in a timely manner.