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This class was a bit less enjoyable than 115A/215A. The material becomes more application based and you really start digging into how to use the subject. It's kind of gross, how mathematical it can be and the class is much slower as a result.
That being said it doesn't stop it from being extremely useful. You learn a lot about molecular structure and finally hit quantum chemistry in the last couple weeks, going over the basics for the popular methods you see in research (Hartree-Fock, Slater orbitals, DFT, the basis for MO theory etc.)
The homework is less frequent and easier. The big thing about this class is that there is a project at the end of the quarter in which you use Gaussian to ask a science based question and write a 3-5 page paper on it.